Short answer: glucosamine and chondroitin for cartilage support, boswellia and turmeric for inflammatory-response support, and vitamin D and calcium for bone health are the main categories with research behind them.
Glucosamine and chondroitin
Glucosamine provides raw material the body uses to help maintain cartilage, while chondroitin helps retain moisture within the cartilage matrix. Together, they're among the most studied compounds in this category, though research on outcomes is mixed across individual studies.
Boswellia and turmeric
Both are botanical extracts traditionally used to support a healthy inflammatory response. Turmeric's curcuminoid content in particular has a substantial modern research base.
Vitamin D and calcium
While primarily associated with bone health, both nutrients play a supporting role in overall musculoskeletal wellness, including joint-adjacent bone structure.
MSM and other supporting compounds
MSM provides organic sulfur, associated with supporting collagen production and connective tissue strength.
See a disclosed six-ingredient formula
JointBrex combines glucosamine, chondroitin, boswellia, turmeric, MSM, and bromelain.
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See our full JointBrex ingredients breakdown, or cartilage and knee health guide for a deeper look at one specific mechanism.